These interfaces are used to integrate computer software with your Zwave network, or for programming or upgrading Zwave networks and devices.
ZWave USB interfaces are the most popular since most computers use USB as their primary interface.
ZWave serial interfaces are used for customer automation projects.
ZWave network WiFi or IP interfaces afford the user the flexibility to install the ZWave interface in a central location. These tend to be specific to a particular home automation hub brand such as Homeseer.